During the American Society of Clinical Oncology Annual Meeting 2018, several studies led or with the participation of SOLTI will be presented.

Below you will find more information:

SOLTI-1303 PATRICIA: A phase II study of palbociclib and trastuzumab ﴾HR+ with or without letrozole﴿ in trastuzumab‐pretreated, postmenopausal patients with HER2‐positive metastatic breast cancer.

Authors: Patricia Villagrasa, Aleix Prat, Mafalda Oliveira, Lorena De La Peña, Xavier Gonzalez, Javier Cortes, Sonia Pernas Simon, Jose Rios, Jordi Canes, Eva Ciruelos

• 2/6/2018, 8:00 AM-11:30 AM

• Hall A

• Poster Session: Breast Cancer—Metastatic

• Abstract TPS1101

Patient (pt)-reported function and symptoms in APHINITY: A randomized comparison of chemotherapy (C) + trastuzumab (H) + placebo (Pla) versus C + H + pertuzumab (P) as adjuvant therapy in pts with HER2-positive early breast cancer (EBC).

Authors: Jose Baselga, Jennifer A. Petersen, Emma Clark, Claire Barton, Eleonora Restuccia, Marion Jennifer Procter, Amir Sonnenblick, Debora Fumagalli, Damian Parlier, Amal Arahmani, Giuseppe Viale, Linda L. Reaby, Elizabeth Frank, Richard D. Gelber, Martine J. Piccart-Gebhart, Jose Bines, Gunter von Minckwitz, Sabina McGarrahan Gasper

• 2/6/2018, 8:00 AM-11:30 AM

• Hall A

• Poster Session: Breast Cancer— Local/Regional/Adjuvant

• Abstract 521

HER2-enriched subtype and ERBB2 mRNA as predictors of pathological complete response following trastuzumab and lapatinib without chemotherapy in early-stage HER2-positive breast cancer: A combined analysis of TBCRC006/023 and PAMELA trials.

Authors: Aleix Prat, Carmine De Angelis, Tomás Pascual, Carolina Gutierrez, Antonio Llombart-Cussac, Tao Wang, Javier Cortes, Brent Neil Rexer, Jamunarani Veeraraghavan, Andres Forero-Torres, Antonio C. Wolff, Serafin Morales, Ian E. Krop, Anne Clarisse Pavlick, Begona Bermejo, Susan G. Hilsenbeck, Mafalda Oliveira, Rachel Schiff, C. Kent Osborne, Mothaffar F. Rimawi

• 2/6/2018, 8:00 AM-11:30 AM

• Hall A

• Poster Session: Breast Cancer—Local/Regional/Adjuvant

• Abstract 509

• Discussed at the Poster Discussion Session on Saturday, June 2, 2018, 3:00 PM - 4:15 PM, in Hall D1

A RB-1 loss of function gene-signature (RBsig) as a tool to predict response to neoadjuvant chemotherapy (CT) plus anti-HER2 agents (H): A substudy of the NeoALTTO trial (BIG 1-06).

Authors: Emanuela Risi, Chiara Biagioni, Matteo Benelli, Ilenia Migliaccio, Amelia McCartney, Martina Bonechi, Cristina Guarducci, Florentine Hilbers, Serena Di Cosimo, Jose Baselga, Dario Romagnoli, Giulia Boccalini, Stefania Vitale, Andrea Grilli, Silvio Bicciato, Christos Sotiriou, Laura Biganzoli, Angelo Di Leo, Luca Malorni

• 2/6/2018, 8:00 AM-11:30 AM

• Hall A

• Poster Session: Breast Cancer—Local/Regional/Adjuvant

• Abstract 570

Association between adaptive immune signature and outcome in HER2-positive breast cancer treated with trastuzumab and lapatinib in the NCCTG-N9831 (Alliance) and NeoALTTO trials.

Authors: Saranya Chumsri, Daniel Serie, Afshin Mashadi-Hossein, Jennifer M. Kachergus, Sarah Warren, Gerardo Colon-Otero, Ann H. Partridge, Lisa A. Carey, Florentine Hilbers, Veerle Van Dooren, Eileen Holmes, Serena Di Cosimo, Olena Werner, Jens Bodo Huober, Jose Baselga, Christos Sotiriou, Edith A. Perez, Amylou C. Dueck, Alvaro Moreno-Aspitia, E Aubrey Thompson

• 2/6/2018, 8:00 AM-11:30 AM

• Hall A

• Poster Session: Breast Cancer—Local/Regional/Adjuvant

• Abstract 577

Pregnancies during and following trastuzumab (T) and/or lapatinib (L) in patients (pts) with HER2-positive (HER2+) early breast cancer (EBC): Analysis from the NeoALTTO (BIG 1-06) and ALTTO (BIG 2-06) trials.

Authors: Matteo Lambertini, Samuel Martel, Christine Campbell, Sebastien Guillaume, Florentine Hilbers, Uwe Schuehly, Larissa Korde, Hatem A Azim, Serena Di Cosimo, Richard Charles Tenglin, Jens Bodo Huober, Jose Baselga, Alvaro Moreno-Aspitia, Martine J. Piccart-Gebhart, Richard D. Gelber, Evandro De Azambuja, Michail Ignatiadis

• 4/6/2018, 1:15 PM-4:45 PM

• Hall A

• Poster Session: Patient and Survivor Care

• Abstract 10065